Dr. Sudipta Seal, Trustee Chair and UCF Pegasus Professor in the Department of Material Science and Engineering at University of Central Florida will give a seminar titled "Oxygen Defects in lanthanides for cEllulaR hypoxia (ODEAR)" to the interested faculty and students at Discovery Park.

Abstract

Engineered rare earth oxide nanoparticles (NP) having mixed valences on their surface are found to be redox active. In case of nanoceria, such valencies can scavenge excess reactive oxygen species (ROS), due to their redox active nature.  Specially designed nanoceria mimics the catalytic properties of antioxidative enzymes and induces protective effect through regenerative scavenging potential and ameliorates the disease states further. In particular, rare earth-NPs trigger angiogenesis by modulating the intracellular oxygen environment and stabilizing hypoxia inducing factor 1alpha endogenously. Furthermore, correlations between angiogenesis induction and Re-NPs physicochemical properties including: surface valence state ratio, surface charge, size, and shape were also explored. Atomistic simulation was also used, in partnership with in vitro and in vivo experimentation, to reveal that the surface reactivity of NPs and facile oxygen transport promotes pro-angiogenesis. Few other research examples will be cited at the end of the talk.

Biography

Sudipta Seal, FASM, University Distinguished Professor, Trustee Chair and UCF Pegasus Professor, joined University of Central Florida (UCF) in fall 1997 after a postdoctoral work at Lawrence Berkeley National Laboratory, University of California, Berkeley. He served as a Director of Advanced Materials Processing Analysis Center, and Nanotechnology Center, currently Chair of newly created Materials Science and Engineering and holds an appointment with College of Medicine. He is the recipient of the 2002: Office of Naval Research Young Investigator Award (ONR-YIP), JSPS fellowship, Alexander Von Humboldt Fellow, ASM IIM Lecturer award, Royal Soc of Eng - Visiting Professor Distinguished Fellowship at Imperial College, UK, etc. He was elected to attend the Frontiers of Eng Symposium by National Academy of Engineering. He is the recipient of Fellow of FASM, FAAAS, FAVS, FIoN, FAIMBE, FNAI, FECS, FMRS, FRSC, FACERS. He is inducted the Florida Hall of Fame of Inventors, elected World Academy Ceramics Academician and a recent recipient of ASM International Albert Sauveur Materials Achievement Award. He has more than 400 journal papers, books and h index> 108. He has more than 87 issued patents and his technology is responsible for various startups.